As it relieves pain, ibuprofen may also diminish male fertility, according to a small but compelling new study.
The research, published in the journal Proceedings of the National Academy of Sciences, followed 31 men ages 18 to 35.
Subjects filled out questionnaires about their general health and gave blood samples. Men were then divided — 14 in an ibuprofen group, 17 in a placebo group.
Ibuprofen subjects were given 600 mg twice a day, or the equivalent of three pills.
The team of investigators from Denmark, France and China found that within two week these men had an elevated risk of compensated hypogonadism, “a condition prevalent among elderly men and associated with reproductive and physical disorders,” researchers note.
The condition, known as testosterone deficiency, is a failure of the testes to produce the male sex hormone testosterone, sperm or both. It is also associated with depression and increased risk for cardiovascular events, including heart failure and stroke.”
“It is sure that these effects are reversible,” study author Bernard Jégou, of the French National Institute of Health and Medical Research, told CNN.
However, it’s unknown whether the health effects of long-term ibuprofen use are reversible, he added.
The new study isn’t the first to suggest that ibuprofen has downsides. In 2017, the NSAID that goes by brand names including Motrin and Advil raises the risk of heart attacks.